STEPHEN L. DODD, Ph.D., F.A.C.S.M.
EDUCATIONAL BACKGROUND
B.S. University of Alabama
M.S. University of Alabama at Birmingham
Ph.D. Louisiana State University
RESEARCH INTERESTS
The research focus of my lab is the study of muscle dysfunction
and adaptation associated with disuse. In addition, we are interested in the
effects of anabolic and catabolic agents on muscle function. Projects are underway
to examine: 1) the role of various protease pathways during unloading, 2) the
role of heat shock proteins during immobilization, and 3) the effects of chemical
denervation on muscle function and adaptation, and 4) the effects of intermittent
ischemia on muscle function and adaptation. The lab is currently funded by grants
from: The American Heart Association, National Aeronautics and Space Administration,
and Ipsen Pharmaceuticals.
RECENT PUBLICATIONS
Smith, I.J. and S. L. Dodd. Calpain activation causes a proteasome-dependent increase in protein degradation and inhibits the Akt signalling pathway in rat diaphragm muscle. Experimental Physiology. 2007, 92(3): 561-573.
Selsby, JT, Rother, S, Tsuda, S, Pracash, O, Quindry, J, and Dodd, SL. Intermittent hyperthermia enhances skeletal muscle regrowth and attenuates oxidative damage following reloading. J Appl Physiol. 2007, 102(4): 1702-07.
Pipinos, I.I., Judge, A. R., Zhen, Z., Selsby, J. T., Swanson, S. A., Johanning, J. M., Baxter, B. T., Lynch, T. G. and Dodd, S. L. Mitochondrial defects and oxidative damage in patients with peripheral arterial disease. Free Radical Biology and Medicine, 2006 41(2): 262-269
Yimlamai, T., S. L. Dodd, S. E. Borst, and S. Park. Clenbuterol Attenuates Hindlimb Unweighting-Induced Muscle Atrophy by Reducing the Activation of the Ubiquitin- Proteasome Pathway. J Appl Physiol. 2005 Jul;99(1):71-80.
Dodd, S.L., J. T. Selsby, A. Payne, A. M. Judge, and C. Dott. Botulinum neurotoxin type A (Dysport) causes shifts in myosin heavy chain composition in muscle. Toxicon 2005 Aug;46(2):196-203.
Selsby, J. T. and S. L. Dodd. Heat treatment reduces oxidative stress and protects muscle mass during immobilization. Am J Physiol Regul Integr Comp Physiol. 2005 Jul;289(1):R134-9.
Selsby, J., A. Judge, T. Yimlamai, C. Leeuwenburgh, and S. L. Dodd. Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats. Exp Gerontology. 2005 40(1-2): pp 37-42.
Judge, A. and S. L. Dodd. Xanthine oxidase and activated neutrophils cause oxidative damage to skeletal muscle following contractile-induced claudication. Am J Physiol Heart Circ Physiol. 2004 286(1):H252-6.
Payne, A. M., S. L. Dodd, and C. Leeuwenburgh. Life-long calorie restriction in Fischer 344 rats attenuates age-related loss in skeletal muscle-specific force and reduces extracellular space. J Appl Physiol. 2003 95: 2554 – 2562.
Judge, A. and S.L. Dodd. Oxidative damage to skeletal muscle following an acute bout of contractile claudication. Atherosclerosis. 2003 171(2): 219-224.